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GENE - TERM ANNOTATION REPORT

RGD ID: 3637
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Scn5a
Name: sodium voltage-gated channel alpha subunit 5
Acc ID: DOID:13884
Term: sick sinus syndrome
Definition: A condition caused by dysfunctions related to the SINOATRIAL NODE including impulse generation (CARDIAC SINUS ARREST) and impulse conduction (SINOATRIAL EXIT BLOCK). It is characterized by persistent BRADYCARDIA, chronic ATRIAL FIBRILLATION, and failure to resume sinus rhythm following CARDIOVERSION. This syndrome can be congenital or acquired, particularly after surgical correction for heart defects.
Definition Source(s): MESH:D012804
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Scn5a ISOSCN5A (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Sick sinus syndrome | ClinVar Annotator: match by term: Sinus node diseasePMID:10377081 PMID:10727653 PMID:10961955 PMID:10973849 PMID:11901046 PMID:12877697 PMID:14523039 PMID:15840476 PMID:16379539 PMID:16453024 PMID:18451998 PMID:18452873 PMID:18508782 PMID:19716085 PMID:19841300 PMID:20110800 PMID:20129283 PMID:20384651 PMID:20448214 PMID:20539757 PMID:21321465 PMID:22090166 PMID:22370247 PMID:22581653 PMID:22789973 PMID:23631430 PMID:24033266 PMID:24439875 PMID:24762805 PMID:24784157 PMID:24871449 PMID:25741868 PMID:26125038 PMID:26467025 PMID:27381756 PMID:27566755 PMID:28492532 PMID:28781849 PMID:29806494 PMID:30385166 PMID:31447099 PMID:31737537 PMID:32096284 PMID:32268277 PMID:32533187 PMID:32533946 PMID:32893267 PMID:33164571 PMID:34135346 PMID:34649698
Scn5a ISSSCN5A (Homo sapiens)13592920MouseDOOMIM:163800 | OMIM:608567 | OMIM:614090 
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