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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3612
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ncor1
Name: nuclear receptor co-repressor 1
Acc ID: CHEBI:16330
Term: 17beta-hydroxy-5alpha-androstan-3-one
Definition: A 17beta-hydroxy steroid that is testosterone in which the 4,5 double bond has been reduced to a single bond with alpha-configuration at position 5.
Chemical ID: MESH:D013196
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ncor1multiple interactionsISONCOR1 (Homo sapiens)6480464CTDDihydrotestosterone inhibits the reaction [NCOR1 protein binds to KLK3 promoter]; methylselenic acid inhibits the reaction [Dihydrotestosterone inhibits the reaction [NCOR1 protein binds to KLK3 promoter]]; NCOR1 protein inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]PMID:16648561 PMID:17804755
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