GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Rnf4 | affects localization | ISO | RNF4 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide affects the localization of RNF4 protein | PMID:20943951 | Rnf4 | multiple interactions | ISO | RNF4 (Homo sapiens) | 6480464 | CTD | [[Arsenic Trioxide results in increased sumoylation of PML protein alternative form] promotes the reaction [PML protein alternative form binds to RNF4 protein]] which results in increased degradation of PML protein alternative form; [[Arsenic Trioxide results in increased sumoylation of PML protein] promotes the reaction [PML protein binds to RNF4 protein]] which results in increased degradation of PML protein; [Arsenic Trioxide results in increased sumoylation of PML protein alternative form] promotes the reaction [PML protein alternative form binds to RNF4 protein]; [Arsenic Trioxide results in increased sumoylation of PML protein] promotes the reaction [PML protein binds to RNF4 protein]; Arsenic Trioxide promotes the reaction [RNF4 protein binds to and results in increased degradation of PML protein modified form]; Arsenic Trioxide promotes the reaction [RNF4 protein binds to SUMO2 protein]; Arsenic Trioxide promotes the reaction [RNF4 protein results in increased degradation of PML protein alternative form]; Arsenic Trioxide promotes the reaction [RNF4 protein results in increased degradation of PML protein]; RNF4 protein affects the reaction [Arsenic Trioxide results in increased expression of ACTA2 mRNA]; RNF4 protein affects the reaction [Arsenic Trioxide results in increased expression of ADIPOQ mRNA]; RNF4 protein affects the reaction [Arsenic Trioxide results in increased expression of SMAD2 mRNA]; RNF4 protein affects the reaction [Arsenic Trioxide results in increased expression of SUMO1 protein]; RNF4 protein affects the reaction [Arsenic Trioxide results in increased expression of TGFB1 mRNA]; RNF4 protein affects the reaction [Arsenic Trioxide results in increased expression of TGFB1 protein]; RNF4 protein promotes the reaction [Arsenic Trioxide affects the localization of SUMO2 protein]; RNF4 protein promotes the reaction [Arsenic Trioxide results in increased degradation of PML protein]; RNF4 protein promotes the reaction [Arsenic Trioxide results in increased ubiquitination of PML protein] | PMID:20943951 PMID:23028697 PMID:26060329 PMID:32240679 | | ||||||||||||||||||||||
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