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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3554
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ren
Name: renin
Acc ID: CHEBI:8364
Term: prazosin
Definition: A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.
Chemical ID: MESH:D011224
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Renincreases transportEXP 6480464CTDPrazosin results in increased transport of REN proteinPMID:3539430
Renmultiple interactionsEXP 6480464CTDPropranolol inhibits the reaction [Prazosin results in increased transport of REN protein]PMID:3539430
Rendecreases activityISOREN (Homo sapiens)6480464CTDPrazosin results in decreased activity of REN proteinPMID:7023672
Renincreases activityISOREN (Homo sapiens)6480464CTDPrazosin results in increased activity of REN proteinPMID:6173514 PMID:6258839 PMID:7023672
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