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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3554
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ren
Name: renin
Acc ID: CHEBI:26708
Term: sodium atom
Definition: An alkali metal atom that has formula Na.
Chemical ID: MESH:D012964
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Renaffects activityEXP 6480464CTDSodium affects the activity of REN proteinPMID:7009830
Renaffects expressionEXP 6480464CTDSodium affects the expression of REN mRNAPMID:12424424
Renmultiple interactionsEXP 6480464CTDNitroprusside affects the reaction [Sodium affects the activity of REN protein]PMID:7009830
Rendecreases expressionISORen1 (Mus musculus)6480464CTDSodium results in decreased expression of REN mRNA; Sodium results in decreased expression of REN proteinPMID:19536436
Rendecreases secretionISORen1 (Mus musculus)6480464CTDSodium results in decreased secretion of REN proteinPMID:19536436
Renincreases activityISOREN (Homo sapiens)6480464CTDSodium deficiency results in increased activity of REN proteinPMID:11299228
Renincreases expressionISORen1 (Mus musculus)6480464CTDSodium deficiency results in increased expression of REN mRNA; Sodium deficiency results in increased expression of REN proteinPMID:19767874
Renmultiple interactionsISORen1 (Mus musculus)6480464CTDSodium inhibits the reaction [Enalapril results in increased expression of REN mRNA]; Sodium inhibits the reaction [Enalapril results in increased expression of REN protein]; Sodium inhibits the reaction [Enalapril results in increased secretion of REN protein]PMID:19536436
Renmultiple interactionsISOREN (Homo sapiens)6480464CTDSodium affects the reaction [Hydrochlorothiazide results in increased activity of REN protein]PMID:1930859
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