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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3540
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rb1
Name: RB transcriptional corepressor 1
Acc ID: CHEBI:95060
Term: dinaciclib
Definition: A pyrazolopyrimidine that is pyrazolo[1,5-a]pyrimidine substituted by ethyl, (2S)-2-(2-hydroxyethyl)piperidin-1-yl, and [(1-oxidopyridin-3-yl)methyl]amino groups at positions 3, 5, and 7, respectively. It is a potent pan-cyclin dependent kinase inhibitor that exhibits antineoplastic activity.
Chemical ID: MESH:C553669
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rb1decreases phosphorylationISORb1 (Mus musculus)6480464CTDdinaciclib results in decreased phosphorylation of RB1 proteinPMID:20663931
Rb1decreases phosphorylationISORB1 (Homo sapiens)6480464CTDdinaciclib results in decreased phosphorylation of RB1 proteinPMID:20663931 PMID:27378523
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