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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3540
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rb1
Name: RB transcriptional corepressor 1
Acc ID: CHEBI:85993
Term: palbociclib
Definition: A member of the class of pyridopyrimidines that is 2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}pyrido[2,3-d]pyrimidin-7-one bearing additional methyl, acetyl and cyclopentyl substituents at positions 5, 6 and 8 respectively. It is used in combination with letrozole for the treatment of metastatic breast cancer.
Chemical ID: MESH:C500026
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rb1affects phosphorylationISORB1 (Homo sapiens)6480464CTDpalbociclib affects the phosphorylation of RB1 proteinPMID:21880723
Rb1affects reactionISORB1 (Homo sapiens)6480464CTDRB1 protein affects the reaction palbociclibPMID:25221644
Rb1affects response to substanceISORB1 (Homo sapiens)6480464CTDRB1 protein affects the susceptibility to palbociclibPMID:20354191 PMID:20473330 PMID:20534551 PMID:24495407 PMID:28620137
Rb1decreases expressionISORB1 (Homo sapiens)6480464CTDpalbociclib results in decreased expression of RB1 mRNA; palbociclib results in decreased expression of RB1 proteinPMID:26318986
Rb1decreases phosphorylationISORB1 (Homo sapiens)6480464CTDpalbociclib results in decreased phosphorylation of RB1 proteinPMID:15542782 PMID:16690963 PMID:17537993 PMID:19435910 PMID:19874578 PMID:20100483 PMID:20534551 PMID:21217777 PMID:21367843 PMID:21593195 PMID:22170262 PMID:22383795 PMID:22761470 PMID:23676220 PMID:23708653 PMID:24736461 PMID:24986516 PMID:26174628 PMID:26873845
Rb1decreases response to substanceISORB1 (Homo sapiens)6480464CTDRB1 gene mutant form results in decreased susceptibility to palbociclib; RB1 mutant form results in decreased susceptibility to palbociclibPMID:21278246 PMID:24986516
Rb1increases phosphorylationISORB1 (Homo sapiens)6480464CTDpalbociclib results in increased phosphorylation of RB1 proteinPMID:23138228
Rb1increases response to substanceISORB1 (Homo sapiens)6480464CTDRB1 protein results in increased susceptibility to palbociclibPMID:21278246 PMID:23708653
Rb1multiple interactionsISORb1 (Mus musculus)6480464CTD[CDKN2A gene mutant form results in increased susceptibility to palbociclib] which results in decreased phosphorylation of RB1 proteinPMID:24098593
Rb1multiple interactionsISORB1 (Homo sapiens)6480464CTDBMS 754807 promotes the reaction [palbociclib results in decreased phosphorylation of RB1 protein]; E2F2 protein inhibits the reaction [palbociclib results in decreased phosphorylation of RB1 protein]; palbociclib affects the reaction [RB1 mutant form results in increased expression of RBL2 protein]; palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of RB1 protein]; palbociclib inhibits the reaction [[PDGFB protein binds to PDGFB protein] inhibits the reaction [RB1 protein binds to SP1 protein]]; palbociclib inhibits the reaction [bisphenol S results in increased phosphorylation of RB1 protein]; palbociclib promotes the reaction [RB1 protein binds to CCNA2 promoter]; palbociclib promotes the reaction [RB1 protein binds to SP1 protein]; palbociclib results in decreased phosphorylation of and results in decreased expression of RB1 protein; RB1 protein affects the reaction [palbociclib inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein]]; RB1 protein affects the reaction [palbociclib inhibits the reaction [Doxorubicin results in increased expression of CCNA2 protein]]; RB1 protein affects the reaction [palbociclib inhibits the reaction [Doxorubicin results in increased expression of E2F1 protein]]; RB1 protein affects the reaction [palbociclib inhibits the reaction [Doxorubicin results in increased expression of TOP2A protein]]; RB1 protein affects the reaction [palbociclib inhibits the reaction [RBL1 protein binds to CCNA2 promoter]]; RB1 protein affects the reaction [palbociclib inhibits the reaction [RBL1 protein binds to PLK1 promoter]]; RB1 protein affects the reaction [palbociclib inhibits the reaction [RBL1 protein binds to RNR2 promoter]]; RB1 protein affects the reaction [palbociclib promotes the reaction [Cycloheximide results in decreased expression of RBL1 protein]]; RB1 protein affects the reaction [palbociclib results in decreased expression of CCNA2 protein]; RB1 protein affects the reaction [palbociclib results in decreased expression of MCM7 protein]; RB1 protein affects the reaction [palbociclib results in decreased expression of MKI67 protein]; RB1 protein affects the reaction [palbociclib results in decreased expression of RBL1 protein]; RB1 protein affects the reaction [palbociclib results in decreased phosphorylation of H2AX protein]; RB1 protein affects the reaction [palbociclib results in decreased phosphorylation of RB1 protein]PMID:20100483 PMID:20473330 PMID:21278246 PMID:21367843 PMID:21880723 PMID:22094256 PMID:22751436 PMID:22761470 PMID:22869556 PMID:24986516 PMID:26318986 PMID:28620137 PMID:30684532
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