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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3535
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rarb
Name: retinoic acid receptor, beta
Acc ID: CHEBI:50131
Term: 5-aza-2'-deoxycytidine
Definition: A 2'-deoxyribonucleoside that has formula C8H12N4O4.
Chemical ID: MESH:C014347
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rarbdecreases metabolic processingISORARB (Homo sapiens)6480464CTDDecitabine results in decreased metabolism of RARB genePMID:17079450
Rarbdecreases methylationISORARB (Homo sapiens)6480464CTDDecitabine results in decreased methylation of RARB promoterPMID:16832676
Rarbincreases expressionISORARB (Homo sapiens)6480464CTDDecitabine results in increased expression of RARB mRNA; Decitabine results in increased expression of RARB proteinPMID:15959780 PMID:17961338 PMID:22082530
Rarbmultiple interactionsISORARB (Homo sapiens)6480464CTD[Decitabine affects the methylation of RARB promoter] which affects the expression of RARB mRNA; [Decitabine co-treated with Tretinoin] results in increased expression of RARB mRNA; [Decitabine co-treated with trichostatin A co-treated with Tretinoin] affects the reaction [H3-4 protein modified form binds to RARB promoter]; [Decitabine co-treated with trichostatin A] affects the reaction [H3-4 protein modified form binds to RARB gene]; [Decitabine co-treated with trichostatin A] results in increased expression of RARB mRNA; [Tretinoin co-treated with Decitabine] results in increased expression of RARB mRNA; Decitabine affects the reaction [H3-4 protein modified form binds to RARB gene]; Decitabine promotes the reaction [Tretinoin results in increased expression of RARB mRNA]; Decitabine promotes the reaction [Tretinoin results in increased expression of RARB protein]; Estradiol promotes the reaction [Decitabine results in increased expression of RARB mRNA]PMID:15959780 PMID:17079450 PMID:18852534 PMID:19524134 PMID:22082530
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