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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3460
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pygb
Name: glycogen phosphorylase B
Acc ID: CHEBI:178199
Term: sotorasib
Definition: A pyridopyrimidine that is pyrido[2,3-d]pyrimidin-2(1H)-one substituted by 4-methyl-2-(propan-2-yl)pyridin-3-yl, (2S)-2-methyl-4-(prop-2-enoyl)piperazin-1-yl, fluoro and 2-fluoro-6-hydroxyphenyl groups at positions 1, 4, 6 and 7, respectively. It is approved for the treatment of patients with non-small cell lung cancer having KRAS(G12C) mutations.
Chemical ID: MESH:C000706028
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pygbmultiple interactionsISOPYGB (Homo sapiens)6480464CTD[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PYGB mRNAPMID:36139627
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