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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3454
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptprj
Name: protein tyrosine phosphatase, receptor type, J
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptprjaffects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of PTPRJ mRNAPMID:22298810 PMID:34747641
Ptprjdecreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of PTPRJ mRNAPMID:33387578
Ptprjdecreases expressionISOPtprj (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of PTPRJ mRNAPMID:19933214
Ptprjincreases expressionISOPTPRJ (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of PTPRJ mRNAPMID:21632981
Ptprjmultiple interactionsISOPtprj (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PTPRJ mRNA; [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of PTPRJ mRNAPMID:17942748 PMID:25975270
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