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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3439
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptgs1
Name: prostaglandin-endoperoxide synthase 1
Acc ID: CHEBI:4696
Term: donepezil hydrochloride
Definition: A racemate comprising equimolar amounts of (R)- and (S)- donepezil hydrochloride. Its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
Chemical ID: MESH:C076946
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptgs1affects expressionISOPTGS1 (Homo sapiens)6480464CTDDonepezil affects the expression of PTGS1 proteinPMID:29777723
Ptgs1decreases expressionISOPTGS1 (Homo sapiens)6480464CTDDonepezil results in decreased expression of PTGS1 mRNAPMID:29777723
Ptgs1multiple interactionsISOPTGS1 (Homo sapiens)6480464CTD[Rivastigmine co-treated with Donepezil] results in decreased expression of PTGS1 mRNA; [Rivastigmine co-treated with Donepezil] results in decreased expression of PTGS1 protein; [Sodium Fluoride co-treated with Donepezil] results in increased expression of PTGS1 mRNA; [Sodium Fluoride co-treated with Donepezil] results in increased expression of PTGS1 protein; [Sodium Fluoride co-treated with Rivastigmine co-treated with Donepezil] results in increased expression of PTGS1 mRNA; [Sodium Fluoride co-treated with Rivastigmine co-treated with Donepezil] results in increased expression of PTGS1 proteinPMID:29777723
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