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GENE - TERM ANNOTATION REPORT

RGD ID: 3417
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prss1
Name: serine protease 1
Acc ID: DOID:4989
Term: pancreatitis
Definition: A pancreas disease that is characterized by inflammation of the pancreas. (DO)
Definition Source(s): https://medlineplus.gov/pancreatitis.html "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prss1 IEP 1599965RGDprotein:increased expression:cytosol 
Prss1susceptibilityISOPRSS1 (Homo sapiens)1599960RGDprotein:mutation: :p.R117H (human) 
Prss1 ISOPRSS1 (Homo sapiens)11554173CTDCTD Direct Evidence: marker/mechanismPMID:23143602
Prss1 ISOPRSS1 (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Recurrent pancreatitisPMID:10381903 PMID:11260229 PMID:15017610 PMID:16036133 PMID:16505482 PMID:17204147 PMID:19191323 PMID:19453252 PMID:19951905 PMID:20502448 PMID:21907651 PMID:22379635 PMID:22427236 PMID:22539344 PMID:22749696 PMID:23143602 PMID:24458023 PMID:25546417 PMID:25741868 PMID:26658045 PMID:28492532 PMID:28502372 PMID:28536777 PMID:29173301 PMID:29215622 PMID:30018304 PMID:30113427 PMID:30850667 PMID:34065437
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