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GENE - TERM ANNOTATION REPORT

RGD ID: 3403
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prl
Name: prolactin
Acc ID: DOID:12700
Term: hyperprolactinemia
Definition: Increased levels of PROLACTIN in the BLOOD, which may be associated with AMENORRHEA and GALACTORRHEA. Relatively common etiologies include PROLACTINOMA, medication effect, KIDNEY FAILURE, granulomatous diseases of the PITUITARY GLAND, and disorders which interfere with the hypothalamic inhibition of prolactin release. Ectopic (non-pituitary) production of prolactin may also occur. (From Joynt, Clinical Neurology, 1992, Ch36, pp77-8)
Definition Source(s): MESH:D006966, http://en.wikipedia.org/wiki/Hyperprolactinemia
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 IEP 1642575RGDprotein:increased expression:serum

 
 ISORGD:73618711554173CTDCTD Direct Evidence: marker/mechanism

PMID:2880862, PMID:2948424, PMID:4001434, PMID:17303669
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.