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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3389
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prkaca
Name: protein kinase cAMP-activated catalytic subunit alpha
Acc ID: CHEBI:27958
Term: cocaine
Definition: A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca.
Chemical ID: MESH:D003042
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prkacaaffects activityEXP 6480464CTDCocaine affects the activity of PRKACA proteinPMID:19457111
Prkacaaffects expressionEXP 6480464CTDCocaine affects the expression of PRKACA proteinPMID:15659224
Prkacamultiple interactionsEXP 6480464CTD[Cocaine affects the activity of PRKACA protein] which affects the phosphorylation of DPYSL2 protein; [Cocaine affects the activity of PRKACA protein] which affects the phosphorylation of GNAO1 protein alternative form; Cocaine affects the activity of and affects the expression of PRKACA proteinPMID:12595601 PMID:19457111
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