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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3387
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prkaa1
Name: protein kinase AMP-activated catalytic subunit alpha 1
Acc ID: CHEBI:42758
Term: aldehydo-D-glucose
Definition: The open chain form of D-glucose.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prkaa1multiple interactionsISOPrkaa1 (Mus musculus)6480464CTD[[PRKAA1 gene mutant form co-treated with PRKAA2 gene mutant form] affects the susceptibility to [Glucose co-treated with S 4048]] which results in decreased abundance of Adenosine Triphosphate; [[PRKAA1 gene mutant form co-treated with PRKAA2 gene mutant form] affects the susceptibility to [Glucose co-treated with S 4048]] which results in increased abundance of Glucose-6-Phosphate; [PRKAA1 gene mutant form co-treated with PRKAA2 gene mutant form] affects the susceptibility to [Glucose co-treated with S 4048]; Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein; PRKAA1 protein affects the reaction [Resveratrol inhibits the reaction [Glucose results in decreased expression of SIRT1 protein]]PMID:19052259 PMID:23090186 PMID:31974165
Prkaa1multiple interactionsISOPRKAA1 (Homo sapiens)6480464CTD6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein]; [Resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein]; Apigenin inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein]; Glucose inhibits the reaction [SGA 360 results in increased phosphorylation of PRKAA1 protein]; Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein; Metformin inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein]; PRKAA1 protein affects the reaction [Metformin inhibits the reaction [Glucose deficiency results in increased chemical synthesis of Reactive Oxygen Species]]; PRKAA1 protein affects the reaction [Ribonucleosides inhibits the reaction [Glucose deficiency results in increased chemical synthesis of Reactive Oxygen Species]]; PRKAA1 protein affects the reaction [Rosiglitazone inhibits the reaction [Glucose affects the localization of NCF1 protein]]; PRKAA1 protein affects the reaction [Rosiglitazone inhibits the reaction [Glucose affects the localization of RAC1 protein]]; PRKAA1 protein affects the reaction [Rosiglitazone inhibits the reaction [Glucose results in increased abundance of Reactive Oxygen Species]]; Resveratrol inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein]PMID:16380484 PMID:16873680 PMID:17916771 PMID:18482975 PMID:31225620
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