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GENE - TERM ANNOTATION REPORT

RGD ID: 3382
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ppp3ca
Name: protein phosphatase 3 catalytic subunit alpha
Acc ID: GO:0097720
Term: calcineurin-mediated signaling
Definition: Any intracellular signal transduction in which the signal is passed on within the cell by activation of a transcription factor as a consequence of dephosphorylation by Ca(2+)-activated calcineurin. The process begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin is a calcium- and calmodulin-dependent serine/threonine protein phosphatase with a conserved function in eukaryotic species from yeast to humans. In yeast and fungi, calcineurin regulates stress signaling and cell cycle, and sporulation and virulence in pathogenic fungi. In metazoans, calcineurin is involved in cell commitment, organogenesis and organ development and immune function of T-lymphocytes. By a conserved mechanism, calcineurin phosphatase activates fungal Crz1 and mammalian NFATc by dephosphorylation and translocation of these transcription factors to the nucleus to regulate gene expression.
Definition Source(s): GOC:di, PMID:25655284, PMID:25878052, PMID:26851544
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppp3cainvolved_inISOPPP3CA (Homo sapiens)1624291RGD PMID:11005320

PMID:11005320
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