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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3337
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pkm
Name: pyruvate kinase M1/2
Acc ID: CHEBI:34575
Term: bisphenol F
Definition: A bisphenol that is methane in which two of the hydrogens have been replaced by 4-hydroxyphenyl groups.
Chemical ID: MESH:C008745
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pkmincreases expressionISOPKM (Homo sapiens)6480464CTDbisphenol F results in increased expression of PKM proteinPMID:34186270
Pkmincreases expressionISOPkm (Mus musculus)6480464CTDbisphenol F results in increased expression of PKM mRNA; bisphenol F results in increased expression of PKM proteinPMID:34147605
Pkmmultiple interactionsISOPKM (Homo sapiens)6480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PKM mRNAPMID:28628672
Pkmmultiple interactionsISOPkm (Mus musculus)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol F results in increased expression of PKM mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol F results in increased expression of PKM protein]; Fulvestrant inhibits the reaction [bisphenol F results in increased expression of PKM protein]PMID:34147605
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