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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3336
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pklr
Name: pyruvate kinase L/R
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pklrdecreases expressionEXP 6480464CTDValproic Acid results in decreased expression of PKLR mRNAPMID:19224547
Pklrdecreases expressionISOPKLR (Homo sapiens)6480464CTDValproic Acid results in decreased expression of PKLR mRNA; Valproic Acid results in decreased expression of PKLR proteinPMID:29154799 PMID:29501571
Pklrincreases methylationISOPKLR (Homo sapiens)6480464CTDValproic Acid results in increased methylation of PKLR genePMID:29154799
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