GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Pik3r1 | decreases expression | EXP | | 6480464 | CTD | bisphenol A results in decreased expression of PIK3R1 mRNA; bisphenol A results in decreased expression of PIK3R1 protein | PMID:22142692 PMID:31551937 | Pik3r1 | decreases phosphorylation | EXP | | 6480464 | CTD | bisphenol A results in decreased phosphorylation of PIK3R1 protein | PMID:34165232 | Pik3r1 | increases expression | EXP | | 6480464 | CTD | bisphenol A results in increased expression of PIK3R1 mRNA | PMID:25181051 PMID:32145629 | Pik3r1 | increases methylation | EXP | | 6480464 | CTD | bisphenol A results in increased methylation of PIK3R1 gene | PMID:28505145 | Pik3r1 | multiple interactions | EXP | | 6480464 | CTD | lithospermate B inhibits the reaction [bisphenol A results in decreased phosphorylation of PIK3R1 protein] | PMID:34165232 | Pik3r1 | decreases expression | ISO | PIK3R1 (Homo sapiens) | 6480464 | CTD | bisphenol A results in decreased expression of PIK3R1 mRNA; bisphenol A results in decreased expression of PIK3R1 protein | PMID:22576693 PMID:34186270 | Pik3r1 | increases expression | ISO | Pik3r1 (Mus musculus) | 6480464 | CTD | bisphenol A results in increased expression of PIK3R1 mRNA | PMID:25594700 PMID:26063408 | Pik3r1 | increases expression | ISO | PIK3R1 (Homo sapiens) | 6480464 | CTD | bisphenol A results in increased expression of PIK3R1 mRNA | PMID:21890461 | Pik3r1 | increases methylation | ISO | PIK3R1 (Homo sapiens) | 6480464 | CTD | bisphenol A results in increased methylation of PIK3R1 gene | PMID:22576693 | Pik3r1 | increases phosphorylation | ISO | PIK3R1 (Homo sapiens) | 6480464 | CTD | bisphenol A results in increased phosphorylation of PIK3R1 protein | PMID:36306618 | Pik3r1 | multiple interactions | ISO | Pik3r1 (Mus musculus) | 6480464 | CTD | [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diethyl phthalate co-treated with di-n-octyl phthalate co-treated with diisodecyl phthalate co-treated with diisononyl phthalate] results in increased expression of PIK3R1 protein; [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with diethyl phthalate co-treated with diisononyl phthalate co-treated with di-n-octyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate] results in increased expression of PIK3R1 protein; [Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of PIK3R1 mRNA | PMID:28433925 PMID:35739755 PMID:37364641 | Pik3r1 | multiple interactions | ISO | PIK3R1 (Homo sapiens) | 6480464 | CTD | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PIK3R1 mRNA; bisphenol A inhibits the reaction [Vincristine results in decreased phosphorylation of PIK3R1 protein]; XBP1 protein affects the reaction [bisphenol A results in increased phosphorylation of PIK3R1 protein] | PMID:28628672 PMID:36181250 PMID:36306618 | | ||||||||||||||||||||||
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