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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3310
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pfkfb4
Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
Acc ID: CHEBI:15379
Term: dioxygen
Definition: An elemental molecule that has formula O2.
Chemical ID: MESH:D010100
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pfkfb4increases expressionISOPFKFB4 (Homo sapiens)6480464CTDOxygen deficiency results in increased expression of PFKFB4 mRNA; Oxygen deficiency results in increased expression of PFKFB4 proteinPMID:16025159 PMID:24236059 PMID:24403227 PMID:25596134 PMID:26516004 PMID:27292261
Pfkfb4multiple interactionsISOPFKFB4 (Homo sapiens)6480464CTD1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine inhibits the reaction [Oxygen deficiency results in increased expression of PFKFB4 mRNA]; Oxygen deficiency promotes the reaction [HIF1A protein results in increased expression of PFKFB4 mRNA]PMID:16025159 PMID:24403227
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