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GENE - TERM ANNOTATION REPORT

RGD ID: 329331850
Species: Pan paniscus
RGD Object: Gene
Symbol: LOC129392969
Name: DDIT3 upstream open reading frame protein
Acc ID: GO:0070059
Term: intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
Definition: The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
Definition Source(s): GOC:mah, GOC:mtg_apoptosis, PMID:18701708
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
LOC129392969involved_inIEAUniProtKB:P35638 or UniProtKB:P35639 or ensembl:ENSMUSP00000026475 or ensembl:ENSP00000340671150520179Ensembl GO_REF:0000107
LOC129392969involved_inIEAPANTHER:PTN000423837150520179TreeGrafter GO_REF:0000118
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