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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3286
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pdha1
Name: pyruvate dehydrogenase E1 subunit alpha 1
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pdha1multiple interactionsEXP 6480464CTD[resveratrol results in increased activity of PDK4 protein] which results in increased phosphorylation of PDHA1 proteinPMID:23824959
Pdha1decreases expressionISOPDHA1 (Homo sapiens)6480464CTDresveratrol results in decreased expression of PDHA1 mRNAPMID:15582268
Pdha1increases expressionISOPdha1 (Mus musculus)6480464CTDresveratrol results in increased expression of PDHA1 proteinPMID:25505154 PMID:25761413
Pdha1multiple interactionsISOPdha1 (Mus musculus)6480464CTDdorsomorphin inhibits the reaction [Resveratrol results in increased expression of PDHA1 protein]; PRKAA1 gene mutant form inhibits the reaction [Resveratrol results in increased expression of PDHA1 protein]PMID:25761413
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