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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3286
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pdha1
Name: pyruvate dehydrogenase E1 subunit alpha 1
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pdha1decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of PDHA1 mRNAPMID:34947998
Pdha1increases expressionEXP 6480464CTDbisphenol A results in increased expression of PDHA1 mRNAPMID:25181051
Pdha1increases methylationEXP 6480464CTDbisphenol A results in increased methylation of PDHA1 genePMID:28505145
Pdha1multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Estradiol] results in decreased expression of PDHA1 mRNAPMID:26496021
Pdha1decreases expressionISOPDHA1 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of PDHA1 mRNAPMID:29275510
Pdha1decreases expressionISOPdha1 (Mus musculus)6480464CTDbisphenol A results in decreased expression of PDHA1 mRNAPMID:22687993
Pdha1increases expressionISOPdha1 (Mus musculus)6480464CTDbisphenol A results in increased expression of PDHA1 mRNAPMID:22687993
Pdha1increases methylationISOPdha1 (Mus musculus)6480464CTDbisphenol A results in increased methylation of PDHA1 promoterPMID:27312807
Pdha1multiple interactionsISOPDHA1 (Homo sapiens)6480464CTD[bisphenol A co-treated with Fulvestrant] results in decreased methylation of PDHA1 genePMID:31601247
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