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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3282
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pdgfa
Name: platelet derived growth factor subunit A
Acc ID: CHEBI:46678
Term: amosite asbestos
Definition: null
Chemical ID: MESH:D017639
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pdgfadecreases expressionEXP 6480464CTDAsbestos, Amosite results in decreased expression of PDGFA mRNAPMID:21797767
Pdgfaincreases expressionEXP 6480464CTDAsbestos, Amosite results in increased expression of PDGFA mRNAPMID:11306436 PMID:12475806
Pdgfamultiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Asbestos, Amosite results in increased expression of PDGFA mRNA]; Deferoxamine inhibits the reaction [Asbestos, Amosite results in increased expression of PDGFA mRNA]; Iron promotes the reaction [Asbestos, Amosite results in increased expression of PDGFA mRNA]; tetramethylthiourea inhibits the reaction [Asbestos, Amosite results in increased expression of PDGFA mRNA]PMID:11306436 PMID:12475806
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