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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3269
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pcna
Name: proliferating cell nuclear antigen
Acc ID: CHEBI:131194
Term: 3,3',5,5'-tetraiodothyroacetic acid
Definition: A monocarboxylic acid that is thyroacetic acid carrying four iodo substituents at positions 3, 3', 5 and 5'.
Chemical ID: MESH:C011126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pcnadecreases expressionISOPCNA (Homo sapiens)6480464CTDtetraiodothyroacetic acid results in decreased expression of PCNA mRNAPMID:35151786
Pcnaincreases expressionISOPCNA (Homo sapiens)6480464CTDtetraiodothyroacetic acid results in increased expression of PCNA proteinPMID:35151786
Pcnamultiple interactionsISOPCNA (Homo sapiens)6480464CTD[tetraiodothyroacetic acid affects the susceptibility to heteronemin] which results in increased expression of PCNA protein; heteronemin inhibits the reaction [tetraiodothyroacetic acid results in increased expression of PCNA protein]; heteronemin promotes the reaction [tetraiodothyroacetic acid results in decreased expression of PCNA mRNA]; tetraiodothyroacetic acid promotes the reaction [heteronemin results in decreased expression of PCNA mRNA]PMID:35151786
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