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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3258
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pax6
Name: paired box 6
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pax6decreases expressionISOPAX6 (Homo sapiens)6480464CTDFluorouracil results in decreased expression of PAX6 mRNAPMID:30518710
Pax6increases expressionISOPax6 (Mus musculus)6480464CTDFluorouracil results in increased expression of PAX6 proteinPMID:21296659
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