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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3249
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Serpine1
Name: serpin family E member 1
Acc ID: CHEBI:4791
Term: endosulfan
Definition: A cyclic sulfite ester that is 1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepine 3-oxide substituted by chloro groups at positions 6, 7, 8, 9, 10 and 10.
Chemical ID: MESH:D004726
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Serpine1increases activityEXP 6480464CTDEndosulfan results in increased activity of SERPINE1 proteinPMID:21804306
Serpine1increases expressionEXP 6480464CTDEndosulfan results in increased expression of SERPINE1 mRNAPMID:29391264
Serpine1multiple interactionsEXP 6480464CTDAscorbic Acid promotes the reaction [Vitamin E inhibits the reaction [Endosulfan results in increased activity of SERPINE1 protein]]; Vitamin E inhibits the reaction [Endosulfan results in increased activity of SERPINE1 protein]PMID:21804306
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