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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3227
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Odc1
Name: ornithine decarboxylase 1
Acc ID: CHEBI:174690
Term: clenbuterol
Definition: A substituted aniline that is 2,6-dichloroaniline in which the hydrogen at position 4 has been replaced by a 2-(tert-butylamino)-1-hydroxyethyl group.
Chemical ID: MESH:D002976
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Odc1increases activityISOOdc1 (Mus musculus)6480464CTDClenbuterol results in increased activity of ODC1 proteinPMID:10353628
Odc1increases stabilityISOOdc1 (Mus musculus)6480464CTDClenbuterol results in increased stability of ODC1 proteinPMID:10353628
Odc1multiple interactionsISOOdc1 (Mus musculus)6480464CTDAlprenolol inhibits the reaction [Clenbuterol results in increased activity of ODC1 protein]; Metoprolol inhibits the reaction [Clenbuterol results in increased activity of ODC1 protein]; Propranolol inhibits the reaction [Clenbuterol results in increased activity of ODC1 protein]PMID:10353628
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