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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3227
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Odc1
Name: ornithine decarboxylase 1
Acc ID: CHEBI:17347
Term: testosterone
Definition: An androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5..
Chemical ID: MESH:D013739
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Odc1decreases expressionISOOdc1 (Mus musculus)6480464CTDTestosterone deficiency results in decreased expression of ODC1 mRNAPMID:33848595
Odc1increases activityISOOdc1 (Mus musculus)6480464CTDTestosterone results in increased activity of ODC1 proteinPMID:11007319 PMID:11139396 PMID:17371283 PMID:9194572
Odc1increases expressionISOOdc1 (Mus musculus)6480464CTDTestosterone results in increased expression of ODC1 mRNAPMID:11007319 PMID:11139396 PMID:20403060 PMID:9194572
Odc1multiple interactionsISOOdc1 (Mus musculus)6480464CTD1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane inhibits the reaction [Testosterone deficiency results in decreased expression of ODC1 mRNA]; CB 3717 inhibits the reaction [Testosterone results in increased activity of ODC1 protein]; CB 3717 inhibits the reaction [Testosterone results in increased expression of ODC1 mRNA]; Reserpine inhibits the reaction [Testosterone results in increased activity of ODC1 protein]; Reserpine inhibits the reaction [Testosterone results in increased expression of ODC1 mRNA]PMID:11139396 PMID:17371283 PMID:33848595 PMID:9194572
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