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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3227
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Odc1
Name: ornithine decarboxylase 1
Acc ID: CHEBI:17148
Term: putrescine
Definition: A four-carbon alkane-alpha,omega-diamine. It is obtained by the breakdown of amino acids and is responsible for the foul odour of putrefying flesh.
Chemical ID: MESH:D011700
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Odc1multiple interactionsEXP 6480464CTD[[Ornithine Decarboxylase Inhibitors results in decreased activity of ODC1 protein] which results in decreased chemical synthesis of Polyamines] which results in decreased abundance of Putrescine; [ODC1 protein results in increased abundance of Putrescine] which affects the localization of TIA1 protein; [ODC1 protein results in increased abundance of Putrescine] which results in decreased expression of EIF3B protein; [ODC1 protein results in increased chemical synthesis of Polyamines] which results in increased abundance of Putrescine; [Pentanoic Acids results in decreased activity of ODC1 protein] which results in decreased abundance of Putrescine; Pentanoic Acids inhibits the reaction [[ODC1 protein results in increased abundance of Putrescine] which affects the localization of TIA1 protein]; Pentanoic Acids inhibits the reaction [[ODC1 protein results in increased abundance of Putrescine] which results in decreased expression of EIF3B protein]PMID:20805360 PMID:22555848
Odc1increases abundanceISOOdc1 (Mus musculus)6480464CTDODC1 protein results in increased abundance of PutrescinePMID:22555848
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