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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3197
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Npy
Name: neuropeptide Y
Acc ID: CHEBI:8093
Term: phenylephrine
Definition: A member of the class of the class of phenylethanolamines that is (1R)-2-(methylamino)-1-phenylethan-1-ol carrying an additional hydroxy substituent at position 3 on the phenyl ring.
Chemical ID: MESH:D010656
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Npymultiple interactionsISONpy (Mus musculus)6480464CTD[Phenylephrine co-treated with ADRA1B protein] results in decreased expression of NPY protein; NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; NPY5R protein affects the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]]; NPY5R protein affects the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]]; Tetradecanoylphorbol Acetate inhibits the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]]; Tetradecanoylphorbol Acetate inhibits the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]]PMID:10660688 PMID:11499749
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