Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - TERM ANNOTATION REPORT

RGD ID: 3186
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nos3
Name: nitric oxide synthase 3
Acc ID: DOID:6432
Term: pulmonary hypertension
Definition: A hypertension characterized by an increase of blood pressure in the pulmonary artery, pulmonary vein or pulmonary capillaries. (DO)
Definition Source(s): https://en.wikipedia.org/wiki/Pulmonary_hypertension "DO" "DO", https://www.ncbi.nlm.nih.gov/pubmed/19555858 "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos3 IDA 4892038RGD  
Nos3treatmentIDA 13504742RGD  
Nos3 IEP 4892004RGDmRNA, protein:increased expression:pulmonary endothelial cell 
Nos3 IMP 4892043RGD  
Nos3 ISONos3 (Mus musculus)4892039RGD  
Nos3 ISONos3 (Mus musculus)5132631RGDRNA:increased expression:lung 
Nos3 ISONOS3 (Homo sapiens)4892009RGDDNA:polymorphism:cds:p.E298D (human) 
Nos3 ISONOS3 (Homo sapiens)4892010RGDprotein:increased expression:arteriole 
Nos3 ISONOS3 (Homo sapiens)4892042RGDassociated with chronic obstructive pulmonary disease; DNA:polymorphism:cds:p.G894T (human) 
Nos3 ISONOS3 (Homo sapiens)5132602RGDassociated with heart disease; protein:increased expression:endothelial cell 
Nos3susceptibilityISONOS3 (Homo sapiens)11533642RGDassociated with Beta-Thalassemia;DNA:repeats:intron: 
Nos3 ISONOS3 (Homo sapiens)11554173CTDCTD Direct Evidence: marker/mechanismPMID:21144100
Go Back to source page   Continue to Ontology report