GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nos3 | decreases expression | EXP | | 6480464 | CTD | Oxygen deficiency results in decreased expression of NOS3 mRNA; Oxygen deficiency results in decreased expression of NOS3 protein | PMID:10747003 PMID:10956627 PMID:28985491 | Nos3 | increases expression | EXP | | 6480464 | CTD | Oxygen deficiency results in increased expression of NOS3 mRNA; Oxygen deficiency results in increased expression of NOS3 protein | PMID:10747003 PMID:10956627 PMID:12829860 PMID:27313889 | Nos3 | multiple interactions | EXP | | 6480464 | CTD | [Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of NOS3 mRNA; cardamonin inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of NOS3 mRNA]; Oxygen deficiency promotes the reaction [AGT protein results in increased expression of NOS3 protein]; Oxygen deficiency results in increased expression of and results in increased phosphorylation of NOS3 protein; sarpogrelate promotes the reaction [Oxygen deficiency results in increased expression of NOS3 protein]; tanshinone inhibits the reaction [Oxygen deficiency results in decreased expression of NOS3 protein]; Valsartan inhibits the reaction [Oxygen deficiency promotes the reaction [AGT protein results in increased expression of NOS3 protein]] | PMID:11897773 PMID:25931318 PMID:28966130 PMID:28985491 | Nos3 | decreases activity | ISO | NOS3 (Homo sapiens) | 6480464 | CTD | Oxygen deficiency results in decreased activity of NOS3 protein | PMID:18001528 | Nos3 | decreases expression | ISO | NOS3 (Homo sapiens) | 6480464 | CTD | Oxygen deficiency results in decreased expression of NOS3 mRNA; Oxygen deficiency results in decreased expression of NOS3 protein | PMID:18001528 PMID:26906511 | Nos3 | increases expression | ISO | NOS3 (Homo sapiens) | 6480464 | CTD | Oxygen deficiency results in increased expression of NOS3 mRNA; Oxygen deficiency results in increased expression of NOS3 protein; Oxygen deficiency results in increased expression of NOS3 protein modified form | PMID:23424623 PMID:23452621 | Nos3 | increases phosphorylation | ISO | Nos3 (Mus musculus) | 6480464 | CTD | Oxygen deficiency results in increased phosphorylation of NOS3 protein | PMID:18436887 | Nos3 | multiple interactions | ISO | Nos3 (Mus musculus) | 6480464 | CTD | valsartan inhibits the reaction [Oxygen deficiency results in increased phosphorylation of NOS3 protein] | PMID:18436887 | Nos3 | multiple interactions | ISO | NOS3 (Homo sapiens) | 6480464 | CTD | 3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of NOS3 protein modified form]; 3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of NOS3 protein]; Acetylcysteine inhibits the reaction [Oxygen deficiency results in decreased expression of NOS3 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of NOS3 protein modified form]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of NOS3 protein]; diphenyleneiodonium inhibits the reaction [Oxygen deficiency results in decreased expression of NOS3 protein]; Folic Acid inhibits the reaction [Oxygen deficiency results in decreased expression of NOS3 protein]; Genistein inhibits the reaction [Oxygen deficiency results in increased expression of NOS3 protein modified form]; Genistein inhibits the reaction [Oxygen deficiency results in increased expression of NOS3 protein]; Plant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of NOS3 protein modified form]; Plant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of NOS3 protein]; Resveratrol inhibits the reaction [Oxygen deficiency results in increased expression of NOS3 protein modified form]; Resveratrol inhibits the reaction [Oxygen deficiency results in increased expression of NOS3 protein]; U 0126 inhibits the reaction [Oxygen deficiency results in decreased expression of NOS3 protein] | PMID:23452621 PMID:26906511 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |