A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.
Chemical ID:
MESH:D013755
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; [Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of NFKBIA protein modified form; Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein]; decursin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NFKBIA protein]; Eugenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of NFKBIA protein modified form]; Hydrolyzable Tannins inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein]; lithol rubine BCA analog promotes the reaction [Tetradecanoylphorbol Acetate results in increased degradation of and results in increased phosphorylation of NFKBIA protein]; lithol rubine BCA promotes the reaction [Tetradecanoylphorbol Acetate results in increased degradation of and results in increased phosphorylation of NFKBIA protein]; piperine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; pterostilbene inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of NFKBIA protein]; Resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of NFKBIA protein]; Resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; Tetradecanoylphorbol Acetate results in increased degradation of and results in increased phosphorylation of NFKBIA protein; Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased degradation of NFKBIA protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of NFKBIA protein]; 3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; 3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of NFKBIA protein]; 5,3'-dihydroxy-3,6,7,8,4'-pentamethoxyflavone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein]; [Arsenic Trioxide co-treated with Tetradecanoylphorbol Acetate] results in decreased degradation of NFKBIA protein; [Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased degradation of NFKBIA protein; [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in decreased expression of NFKBIA mRNA; [Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased degradation of NFKBIA protein; [Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased degradation of NFKBIA protein; [Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased degradation of NFKBIA protein; [Tetradecanoylphorbol Acetate co-treated with Plant Preparations] results in increased degradation of NFKBIA protein; [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein] which results in increased activity of and results in increased localization of RELA protein; [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased degradation of NFKBIA protein] which results in increased localization of and results in increased activity of NFKB1 protein; [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased degradation of NFKBIA protein] which results in increased localization of and results in increased activity of RELA protein; Amiodarone inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased degradation of NFKBIA protein]; antroquinonol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of NFKBIA protein]; artenimol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein]; BAG1 protein promotes the reaction [[Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein] which results in increased localization of and results in increased activity of RELA protein]; BAG1 protein promotes the reaction [[Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased degradation of NFKBIA protein] which results in increased localization of and results in increased activity of NFKB1 protein]; BAG1 protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased degradation of NFKBIA protein]; capsiate analog inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Plant Preparations] results in increased degradation of NFKBIA protein]; CBR1 protein modified form inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; chrysin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased degradation of NFKBIA protein]; Clenbuterol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein]; Cycloheximide promotes the reaction [Tetradecanoylphorbol Acetate results in decreased expression of NFKBIA protein]; Cycloheximide promotes the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein]; Dobutamine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein]; eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein]; galangin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased degradation of NFKBIA protein]; kaempferol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein]; kahweol acetate inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of NFKBIA protein]; MIR146A mRNA affects the reaction [Tetradecanoylphorbol Acetate results in decreased phosphorylation of NFKBIA protein]; NFKBIA protein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CXCL8 protein]; NFKBIA protein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL1B protein]; NFKBIA protein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL1RN protein]; NFKBIA protein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL6 protein]; NFKBIA protein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNF mRNA]; NFKBIA protein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNF protein]; NFKBIA protein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFRSF1B protein]; Oils, Volatile inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased degradation of NFKBIA protein]; piperine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein]; Plant Extracts inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased degradation of NFKBIA protein]; Plant Oils inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased degradation of NFKBIA protein]; platyconic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NFKBIA mRNA]; Quercetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased degradation of NFKBIA protein]; Quercetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein]; Resveratrol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased degradation of NFKBIA protein]; scoparone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of NFKBIA protein]; shogaol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased expression of NFKBIA protein]; Tetradecanoylphorbol Acetate promotes the reaction [Cycloheximide results in decreased expression of NFKBIA protein]; Tetradecanoylphorbol Acetate promotes the reaction [Cycloheximide results in increased degradation of NFKBIA protein]; Tetradecanoylphorbol Acetate results in increased degradation of and results in increased phosphorylation of NFKBIA protein; Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased degradation of NFKBIA protein; Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased expression of NFKBIA protein; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein]
