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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3171
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfkbia
Name: NFKB inhibitor alpha
Acc ID: CHEBI:18388
Term: apigenin
Definition: A trihydroxyflavone that is flavone substituted by hydroxy groups at positions 4', 5 and 7. It induces autophagy in leukaemia cells.
Chemical ID: MESH:D047310
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfkbiamultiple interactionsEXP 6480464CTDApigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased degradation of NFKBIA protein]; Apigenin inhibits the reaction [Freund's Adjuvant results in increased phosphorylation of NFKBIA protein]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in decreased expression of NFKBIA protein]PMID:18090225 PMID:25557508 PMID:25935278
Nfkbiaaffects degradationISONFKBIA (Homo sapiens)6480464CTDApigenin affects the degradation of NFKBIA proteinPMID:24148603
Nfkbiamultiple interactionsISONfkbia (Mus musculus)6480464CTDApigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]; Apigenin inhibits the reaction [Ovalbumin results in increased phosphorylation of NFKBIA protein]PMID:16934226 PMID:36350155
Nfkbiamultiple interactionsISONFKBIA (Homo sapiens)6480464CTDApigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]; Apigenin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Apigenin inhibits the reaction [TNF protein results in increased phosphorylation of [NFKBIB protein binds to NFKBIA protein]]; Apigenin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]PMID:15322261 PMID:24148603 PMID:36350155
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