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GENE - TERM ANNOTATION REPORT

RGD ID: 3140
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Myh9
Name: myosin, heavy chain 9
Acc ID: DOID:783
Term: end stage renal failure
Definition: The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
Definition Source(s): MESH:D007676
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 ISORGD:7324016903237RGDassociated with hypertension, glomerulosclerosis, focal segmental, DNA:SNPs: :rs4821480, rs2032487, rs4821481(human)

 
 ISORGD:7324016903238RGDassociated with diabetes mellitus, type 2, DNA:SNPs: :

 
 ISORGD:7324016903239RGDassociated with hypertension, DNA:polymorphisms:multiple:

 
 ISORGD:7324016903243RGDDNA:SNPs:multiple:

 
 ISORGD:7324016903256RGDassociated with diabetes mellitus, type 2, DNA:SNPs: :

 
 ISORGD:73240111554173CTDCTD Direct Evidence: marker/mechanism

PMID:18794854, PMID:18794856
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.