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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3130
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Myc
Name: MYC proto-oncogene, bHLH transcription factor
Acc ID: CHEBI:8069
Term: phenobarbital
Definition: A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Chemical ID: MESH:D010634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mycdecreases methylationEXP 6480464CTDPhenobarbital results in decreased methylation of MYC promoterPMID:30141584
Mycincreases expressionEXP 6480464CTDPhenobarbital results in increased expression of MYC mRNAPMID:19162173 PMID:30141584
Mycmultiple interactionsEXP 6480464CTD[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of MYC mRNA; [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of MYC proteinPMID:20935162 PMID:7576107
Mycaffects expressionISOMYC (Homo sapiens)6480464CTDPhenobarbital affects the expression of MYC mRNAPMID:19159669
Mycincreases expressionISOMyc (Mus musculus)6480464CTDPhenobarbital results in increased expression of MYC mRNAPMID:19482888
Mycincreases expressionISOMYC (Homo sapiens)6480464CTDPhenobarbital results in increased expression of MYC mRNAPMID:19084549
Mycincreases response to substanceISOMyc (Mus musculus)6480464CTDMYC gene results in increased susceptibility to PhenobarbitalPMID:8807143
Mycmultiple interactionsISOMyc (Mus musculus)6480464CTD[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of MYC mRNA; [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of MYC protein; [MYC gene co-treated with HGF gene] results in decreased susceptibility to Phenobarbital; [Phenobarbital co-treated with MYC protein] results in increased expression of BAX protein; NR1I3 protein affects the reaction [Phenobarbital results in increased expression of MYC mRNA]; NR1I3 protein promotes the reaction [Phenobarbital results in increased expression of MYC mRNA]; Phenobarbital inhibits the reaction [MYC protein results in decreased expression of BCL2 protein]; Phenobarbital inhibits the reaction [MYC protein results in increased expression of BAX protein]; Phenobarbital inhibits the reaction [MYC protein results in increased expression of TRP53 protein]PMID:10425313 PMID:10449034 PMID:19482888 PMID:24535843 PMID:8807143 PMID:9230198
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