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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3130
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Myc
Name: MYC proto-oncogene, bHLH transcription factor
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mycaffects expressionISOMYC (Homo sapiens)6480464CTDFluorouracil affects the expression of MYC mRNAPMID:23941782 PMID:34151400
Mycaffects response to substanceISOMYC (Homo sapiens)6480464CTDMYC protein affects the susceptibility to FluorouracilPMID:18802399
Mycdecreases expressionISOMyc (Mus musculus)6480464CTDFluorouracil results in decreased expression of MYC mRNAPMID:26272751
Mycdecreases expressionISOMYC (Homo sapiens)6480464CTDFluorouracil results in decreased expression of MYC mRNA; Fluorouracil results in decreased expression of MYC proteinPMID:15585135 PMID:16557594 PMID:16709241 PMID:16803524
Mycdecreases response to substanceISOMYC (Homo sapiens)6480464CTDMYC protein results in decreased susceptibility to FluorouracilPMID:17628013
Mycincreases expressionISOMYC (Homo sapiens)6480464CTDFluorouracil results in increased expression of MYC proteinPMID:16709241
Mycmultiple interactionsISOMYC (Homo sapiens)6480464CTD[Cadmium Chloride co-treated with Fluorouracil] affects the expression of MYC protein; [Fluorouracil co-treated with Cadmium Chloride] affects the expression of MYC mRNA; TP53 protein promotes the reaction [Fluorouracil results in decreased expression of MYC mRNA]PMID:16557594 PMID:23941782
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