GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Myc | multiple interactions | EXP | | 6480464 | CTD | Arsenic Trioxide promotes the reaction [Berberine affects the localization of MYC protein] | PMID:18294404 | Myc | affects methylation | ISO | MYC (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide affects the methylation of MYC promoter | PMID:26046465 | Myc | decreases expression | ISO | MYC (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in decreased expression of MYC mRNA; Arsenic Trioxide results in decreased expression of MYC protein | PMID:11714746 PMID:11775218 PMID:12903497 PMID:12903512 PMID:15283693 PMID:19408305 PMID:20953137 PMID:22944098 PMID:25174355 PMID:25335113 PMID:25436934 PMID:26966376 PMID:27039805 PMID:28565807 PMID:28901456 PMID:29059232 PMID:29574283 PMID:30093655 PMID:34413873 | Myc | increases expression | ISO | MYC (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in increased expression of MYC mRNA; Arsenic Trioxide results in increased expression of MYC protein | PMID:19769630 PMID:23851143 PMID:26046465 PMID:29355690 PMID:29486283 | Myc | multiple interactions | ISO | Myc (Mus musculus) | 6480464 | CTD | [Genistein co-treated with Arsenic Trioxide] results in decreased expression of MYC protein | PMID:21078540 | Myc | multiple interactions | ISO | MYC (Homo sapiens) | 6480464 | CTD | [Arsenic Trioxide co-treated with Aprepitant] results in decreased expression of MYC mRNA; [Arsenic Trioxide co-treated with Cisplatin] results in decreased expression of MYC mRNA; [Arsenic Trioxide co-treated with Cisplatin] results in decreased expression of MYC protein; [Arsenic Trioxide co-treated with Tretinoin] results in decreased expression of MYC protein; [Genistein co-treated with Arsenic Trioxide] results in decreased expression of MYC protein; [NVP-BKM120 co-treated with Arsenic Trioxide] results in decreased expression of MYC mRNA; [ruxolitinib co-treated with Arsenic Trioxide] results in decreased expression of MYC mRNA; Acetylcysteine inhibits the reaction [[Arsenic Trioxide co-treated with Cisplatin] results in decreased expression of MYC protein]; Arsenic Trioxide inhibits the reaction [Lithium Chloride results in increased expression of MYC protein]; Arsenic Trioxide inhibits the reaction [MYC protein binds to PRDX3 protein]; Arsenic Trioxide inhibits the reaction [MYC protein results in increased activity of PRDX3 protein]; Arsenic Trioxide inhibits the reaction [SP1 protein binds to MYC promoter]; Arsenic Trioxide promotes the reaction [MSI1 protein results in increased expression of MYC protein]; Arsenic Trioxide promotes the reaction [Tretinoin results in decreased expression of MYC protein]; BCL2 protein inhibits the reaction [Arsenic Trioxide results in decreased expression of MYC mRNA]; CAB39L protein alternative form inhibits the reaction [Arsenic Trioxide results in decreased expression of MYC protein]; EIF2AK2 protein affects the reaction [Arsenic Trioxide promotes the reaction [MSI1 protein results in increased expression of MYC protein]]; EIF2AK2 protein affects the reaction [Arsenic Trioxide results in increased expression of MYC protein]; EIF2S1 protein affects the reaction [Arsenic Trioxide promotes the reaction [MSI1 protein results in increased expression of MYC protein]]; GH1 protein promotes the reaction [Arsenic Trioxide results in increased expression of MYC mRNA]; MSI1 protein affects the reaction [Arsenic Trioxide results in increased expression of MYC protein]; Tretinoin promotes the reaction [Arsenic Trioxide results in decreased expression of MYC protein]; VS-5584 promotes the reaction [Arsenic Trioxide results in decreased expression of MYC mRNA] | PMID:11775218 PMID:15761015 PMID:19408305 PMID:21078540 PMID:23851143 PMID:28901456 PMID:29059232 PMID:29486283 PMID:29574283 PMID:29944906 PMID:30012499 PMID:30093655 PMID:30145367 PMID:30316766 PMID:31539632 | | ||||||||||||||||||||||
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