GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mt1 | affects expression | EXP | | 6480464 | CTD | Zinc affects the expression of MT1A mRNA | PMID:14690761 | Mt1 | decreases expression | EXP | | 6480464 | CTD | Zinc deficiency results in decreased expression of MT1A mRNA | PMID:11717422 PMID:12514266 PMID:12672911 PMID:3609024 PMID:9278552 PMID:9649590 | Mt1 | increases expression | EXP | | 6480464 | CTD | Zinc deficiency results in increased expression of MT1A mRNA; Zinc deficiency results in increased expression of MT1A protein; Zinc results in increased expression of MT1A mRNA | PMID:11311571 PMID:15952664 PMID:16140947 PMID:17074742 PMID:17241390 PMID:18172885 PMID:19369054 PMID:7564896 | Mt1 | multiple interactions | EXP | | 6480464 | CTD | 1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene promotes the reaction [Zinc results in increased expression of MT1A mRNA]; [Butyrates co-treated with Zinc] results in increased expression of MT1A mRNA; [Folic Acid co-treated with Zinc] inhibits the reaction [Homocysteine results in decreased expression of MT1A mRNA]; [Zinc co-treated with Iron] results in increased expression of and affects the localization of MT1A protein; IL1A protein inhibits the reaction [Zinc deficiency results in decreased expression of MT1A mRNA]; Zinc affects the reaction [Zinc deficiency results in increased expression of MT1A mRNA]; Zinc affects the reaction [Zinc deficiency results in increased expression of MT1A protein]; Zinc deficiency inhibits the reaction [IL1A protein results in increased expression of MT1A mRNA]; Zinc inhibits the reaction [Cadmium Chloride results in increased expression of MT1A mRNA]; Zinc inhibits the reaction [Homocysteine results in decreased expression of MT1A mRNA]; Zinc promotes the reaction [Butyrates results in increased expression of MT1A protein]; Zinc promotes the reaction [Daunorubicin results in increased expression of MT1A mRNA]; Zinc promotes the reaction [Daunorubicin results in increased expression of MT1A protein]; Zinc promotes the reaction [Streptozocin results in increased expression of MT1A mRNA]; Zinc results in increased expression of and affects the localization of MT1A protein; Zinc Sulfate inhibits the reaction [Zinc deficiency results in decreased expression of MT1A mRNA] | PMID:11311571 PMID:12204545 PMID:12514266 PMID:1597404 PMID:16140947 PMID:17241390 PMID:19369054 PMID:19641857 PMID:20096345 PMID:3609024 PMID:9278552 PMID:9649590 | Mt1 | affects binding | ISO | MT1A (Homo sapiens) | 6480464 | CTD | MT1A protein binds to Zinc; Zinc binds to MT1A protein | PMID:10548558 PMID:20329713 PMID:22242602 | Mt1 | increases expression | ISO | MT1A (Homo sapiens) | 6480464 | CTD | Zinc results in increased expression of MT1A mRNA | PMID:11168427 PMID:12716893 PMID:14568174 PMID:15867382 PMID:17363595 PMID:17409696 PMID:20043934 | Mt1 | multiple interactions | ISO | MT1A (Homo sapiens) | 6480464 | CTD | 1L-6-hydroxymethyl-chiro-inositol 2(R)-2-O-methyl-3-O-octadecylcarbonate promotes the reaction [Zinc results in increased expression of MT1A mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Zinc results in increased expression of MT1A mRNA]; [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Zinc co-treated with ochratoxin A] results in increased expression of MT1A mRNA; [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Zinc] results in increased expression of MT1A mRNA; [Zinc co-treated with motexafin gadolinium] results in increased expression of MT1A mRNA; chromium hexavalent ion inhibits the reaction [Zinc results in increased expression of MT1A mRNA]; MT1A gene polymorphism affects the reaction [Zinc results in decreased expression of CCL2 protein]; MT1A gene polymorphism affects the reaction [Zinc results in decreased expression of FABP4 mRNA]; MT1A gene polymorphism affects the reaction [Zinc results in decreased expression of IL1B mRNA]; MT1A gene polymorphism affects the reaction [Zinc results in decreased expression of IL1R2 mRNA]; MT1A gene polymorphism affects the reaction [Zinc results in decreased expression of IL6 mRNA]; MT1A gene polymorphism affects the reaction [Zinc results in decreased expression of IL6 protein]; MT1A gene polymorphism affects the reaction [Zinc results in decreased expression of LEP mRNA]; tris(1,10-phenanthroline)chromium(III) chloride inhibits the reaction [Zinc results in increased expression of MT1A mRNA]; Zinc promotes the reaction [ochratoxin A results in increased expression of MT1A mRNA] | PMID:12716893 PMID:15867382 PMID:17363595 PMID:18215484 PMID:18316168 PMID:19720134 PMID:20043934 PMID:23391613 | | ||||||||||||||||||||||
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