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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3112
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc1
Name: ATP binding cassette subfamily C member 1
Acc ID: CHEBI:34159
Term: 15-deoxy-Delta(12,14)-prostaglandin J2
Definition: A prostaglandin J derivative comprising prostaglandin J2 lacking the 15-hydroxy group and having C=C double bonds at the 12- and 14-positions.
Chemical ID: MESH:C097240
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc1affects exportISOABCC1 (Homo sapiens)6480464CTDABCC1 protein affects the export of 15-deoxy-delta(12,14)-prostaglandin J2 analogPMID:14979731
Abcc1affects glutathionylationISOABCC1 (Homo sapiens)6480464CTDABCC1 protein affects the glutathionylation of 15-deoxy-delta(12,14)-prostaglandin J2PMID:21728338
Abcc1increases transportISOABCC1 (Homo sapiens)6480464CTDABCC1 protein results in increased transport of 15-deoxy-delta(12,14)-prostaglandin J2 metabolitePMID:21728338
Abcc1multiple interactionsISOABCC1 (Homo sapiens)6480464CTD[ABCC1 protein results in increased transport of 15-deoxy-delta(12,14)-prostaglandin J2 metabolite] affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]; [verlukast binds to and results in decreased activity of ABCC1 protein] inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]; ABCC1 protein affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [NFE2L2 protein results in increased expression of GCLC protein]]; ABCC1 protein affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]PMID:21728338
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