Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3112
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc1
Name: ATP binding cassette subfamily C member 1
Acc ID: CHEBI:28499
Term: kaempferol
Definition: A tetrahydroxyflavone in which the four hydroxy groups are located at positions 3, 5, 7 and 4'. Acting as an antioxidant by reducing oxidative stress, it is currently under consideration as a possible cancer treatment.
Chemical ID: MESH:C006552
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc1affects activityISOABCC1 (Homo sapiens)6480464CTDkaempferol affects the activity of ABCC1 proteinPMID:15796199
Abcc1decreases activityISOABCC1 (Homo sapiens)6480464CTDkaempferol results in decreased activity of ABCC1 proteinPMID:15670588
Abcc1increases activityISOABCC1 (Homo sapiens)6480464CTDkaempferol results in increased activity of ABCC1 proteinPMID:11306701
Abcc1multiple interactionsISOABCC1 (Homo sapiens)6480464CTDkaempferol affects the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; kaempferol inhibits the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]PMID:11306701
Go Back to source page   Continue to Ontology report