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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3082
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Met
Name: MET proto-oncogene, receptor tyrosine kinase
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Metdecreases expressionISOMET (Homo sapiens)6480464CTDQuercetin analog results in decreased expression of MET protein; Quercetin results in decreased expression of MET mRNA; Quercetin results in decreased expression of MET proteinPMID:19877526 PMID:21632981 PMID:25971889
Metmultiple interactionsISOMET (Homo sapiens)6480464CTDPalmitic Acid inhibits the reaction [Quercetin results in decreased expression of MET protein]; Quercetin inhibits the reaction [bis(sulfosuccinimidyl)suberate promotes the reaction [MET protein binds to MET protein]]; Quercetin inhibits the reaction [HGF protein promotes the reaction [bis(sulfosuccinimidyl)suberate promotes the reaction [MET protein binds to MET protein]]]; Quercetin inhibits the reaction [HGF protein results in increased expression of and results in increased phosphorylation of MET protein]; Quercetin inhibits the reaction [HGF protein results in increased phosphorylation of MET protein]PMID:19244381 PMID:25971889
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