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GENE - TERM ANNOTATION REPORT

RGD ID: 3078
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Men1
Name: menin 1
Acc ID: DOID:9007071
Term: Hereditary Neoplastic Syndromes
Definition: The condition of a pattern of malignancies within a family, but not every individual's necessarily having the same neoplasm. Characteristically the tumor tends to occur at an earlier than average age, individuals may have more than one primary tumor, the tumors may be multicentric, usually more than 25 percent of the individuals in direct lineal descent from the proband are affected, and the cancer predisposition in these families behaves as an autosomal dominant trait with about 60 percent penetrance.
Definition Source(s): MESH:D009386
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:10027401, PMID:10594843, PMID:11836268, PMID:12112656, PMID:26767918, PMID:9683585, PMID:9888389
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:10090472, PMID:10576763, PMID:12652570, PMID:28492532
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:10090472, PMID:10634422, PMID:10759881, PMID:10843194, PMID:11807402, PMID:17590169, PMID:17623761, PMID:17953629, PMID:25741868, PMID:26467025, PMID:28492532, PMID:9215689, PMID:9407947, PMID:9463336, PMID:9683585, PMID:9888389, PMID:9935177
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:10090472, PMID:11578300, PMID:15331604, PMID:16449969, PMID:17158764, PMID:17853334, PMID:28492532
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:10090472, PMID:15522929, PMID:15714081, PMID:17853334, PMID:24033266, PMID:28492532, PMID:9103196
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:10090472, PMID:18753104, PMID:25309785
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:10090472, PMID:22470073
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:10395246, PMID:10730900, PMID:15026366, PMID:15714081, PMID:22549346, PMID:24997771, PMID:28492532, PMID:9832038
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:10439966, PMID:22026581, PMID:28492532, PMID:9463336
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:10576763
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:10594843, PMID:11836268, PMID:12112656, PMID:9683585, PMID:9888389
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:10598193
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:10612827, PMID:11836268, PMID:12112656, PMID:28492532
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:10612827, PMID:12652570, PMID:23321498, PMID:25741868, PMID:28492532
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:10612827, PMID:15714081, PMID:26515642, PMID:28492532
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:10617276
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:10617276, PMID:11454510, PMID:17711922, PMID:21819486, PMID:22026581, PMID:28492532, PMID:9103196, PMID:9215689, PMID:9354421
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:10617276, PMID:12112656, PMID:12807514, PMID:15254225, PMID:21819486, PMID:22090276, PMID:28492532, PMID:9683585
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:10647896, PMID:25741868, PMID:28492532
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:10660339, PMID:12049533, PMID:17853334
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:10664520, PMID:11836268, PMID:15670192, PMID:15714081, PMID:17555499, PMID:17879353, PMID:20833329, PMID:22577108, PMID:25309785, PMID:25525159, PMID:25824098, PMID:28492532, PMID:29036195, PMID:9215690, PMID:9329390
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:10664520, PMID:12166655, PMID:12746426, PMID:17623761, PMID:28492532
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:10664520, PMID:24033266, PMID:28492532
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:10730900, PMID:10762295, PMID:11303512, PMID:11836268, PMID:12050235, PMID:12112656, PMID:12652570, PMID:14985373, PMID:15044367, PMID:15254225, PMID:16430712, PMID:17766710, PMID:21819486, PMID:24033266, PMID:26905068, PMID:28492532, PMID:9215689, PMID:9241276, PMID:9463336, PMID:9683585, PMID:9709921
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:10849016, PMID:11836268, PMID:12112656, PMID:9683585
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:10849016, PMID:12112656
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:10856877, PMID:15635078, PMID:17623761, PMID:17879353, PMID:20833329, PMID:23093699, PMID:24033266, PMID:24599222, PMID:24915123, PMID:25309785, PMID:28492532, PMID:9103196, PMID:9215690, PMID:9498491
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:10870030, PMID:26467025, PMID:28492532, PMID:29264567, PMID:9103196, PMID:9215689, PMID:9463336
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:10918183, PMID:17623761, PMID:17879353, PMID:23933118, PMID:25741868, PMID:28492532
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:10931084, PMID:17623761, PMID:20660572, PMID:21819486, PMID:22936661, PMID:28492532
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:10980535, PMID:12112656, PMID:18045958, PMID:25525159, PMID:28492532, PMID:9215690, PMID:9683585
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:10993646, PMID:12112656, PMID:21819486, PMID:23052745, PMID:9506756
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:11134142, PMID:14508515, PMID:21819486, PMID:21917868, PMID:22090276, PMID:23648481, PMID:9215689
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:112112656, PMID:28492532
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:11221882, PMID:12509449, PMID:19074834, PMID:22090276, PMID:22327296, PMID:23648481, PMID:28492532, PMID:9215689, PMID:9989505
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:11524904, PMID:11836268, PMID:12509449, PMID:14508515, PMID:15714081, PMID:22327296, PMID:9215689
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:11578300
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:12016470, PMID:19068082, PMID:21819486, PMID:28492532
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:12049533, PMID:15714081, PMID:16449969, PMID:28492532
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:12049533, PMID:17853334, PMID:28492532
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:12050235, PMID:15331604, PMID:16449969, PMID:17879353, PMID:28492532
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:12108687, PMID:28492532
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:12112656, PMID:12213668, PMID:15635078, PMID:15670192, PMID:17065424, PMID:17853334, PMID:17879353, PMID:19041010, PMID:20367983, PMID:2134015, PMID:21340156, PMID:22470073, PMID:23321498, PMID:24915123, PMID:25291050, PMID:25741868, PMID:28492532, PMID:9215689
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:12112656, PMID:15635078
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:12112656, PMID:17853334, PMID:28492532
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:12112656, PMID:9820618
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:12213668, PMID:15714081, PMID:28492532, PMID:28736585, PMID:29036195
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:12368203, PMID:22327296
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:12652570
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:12652570, PMID:15870131
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:12791038, PMID:22026581, PMID:28492532, PMID:9215689
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:15331604, PMID:15714081, PMID:16449969, PMID:17853334, PMID:19491073, PMID:22187299, PMID:28492532
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:15331604, PMID:16449969, PMID:17879353, PMID:21819486, PMID:28492532, PMID:2857681, PMID:6108714, PMID:9554741
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:15331604, PMID:16449969, PMID:28492532, PMID:9215690
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:15670192, PMID:28492532
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:15714081, PMID:21127195, PMID:21819486, PMID:22090276, PMID:22327296, PMID:28492532, PMID:9103196
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:15714081, PMID:28492532
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:15730416
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:16449969, PMID:16840830, PMID:22327296
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:16484744
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:16563611
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:16563611, PMID:17879353, PMID:20833329, PMID:23933118, PMID:25741868, PMID:28492532, PMID:9103196, PMID:9215689
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:16563611, PMID:17879353, PMID:21819486, PMID:24033266, PMID:25637381, PMID:28492532
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:16563611, PMID:19068082, PMID:21819486, PMID:22995991, PMID:26332594, PMID:28492532
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:16699310, PMID:22327296
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:17194968, PMID:24033266, PMID:28492532
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:17623761
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:17623761, PMID:22327296, PMID:25741868, PMID:28492532
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:17623761, PMID:22327296, PMID:27212590
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:17879353, PMID:23933118, PMID:25741868, PMID:28492532
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:20142633, PMID:22327296
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:21454242
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:21819486, PMID:22703879, PMID:24728327, PMID:24997771, PMID:25637381, PMID:25741868, PMID:28492532
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:22090276, PMID:25741868, PMID:28492532, PMID:9215689
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:22187299, PMID:24033266, PMID:25741868, PMID:28492532
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:22327296
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:22327296, PMID:28492532
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:22703879, PMID:28492532
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:23933118, PMID:28492532
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:24033266, PMID:25741868, PMID:28492532
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:25309785, PMID:26530882, PMID:28492532
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:25741868
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:25741868, PMID:28492532
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:26239674
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:26767918
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:26767918, PMID:28492532
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:28492532
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:9215689, PMID:9439676
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:9683585
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

 
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:10664520, PMID:12112656, PMID:17853334, PMID:22666734, PMID:25525159, PMID:28492532, PMID:9683585, PMID:9888389
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:10664520, PMID:15635078, PMID:15670192, PMID:16563611, PMID:17879353, PMID:22026581, PMID:23154721, PMID:24599222, PMID:25309785, PMID:25741868, PMID:26767918, PMID:28492532, PMID:9103196, PMID:9709921
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:11578300, PMID:15331604, PMID:16449969, PMID:17853334, PMID:22470073, PMID:24218143, PMID:28492532, PMID:9103196
 ISORGD:7364438554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:15714081
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.