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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3051
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slco2a1
Name: solute carrier organic anion transporter family, member 2a1
Acc ID: CHEBI:3139
Term: bleomycin A2
Definition: A bleomycin that has formula C55H84N17O21S3.
Chemical ID: MESH:D001761
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slco2a1increases response to substanceISOSlco2a1 (Mus musculus)6480464CTDSLCO2A1 gene mutant form results in increased susceptibility to BleomycinPMID:32828905
Slco2a1multiple interactionsISOSlco2a1 (Mus musculus)6480464CTD[SLCO2A1 gene mutant form results in increased susceptibility to Bleomycin] which results in increased expression of TNF mRNA; SLCO2A1 gene mutant form promotes the reaction [Bleomycin results in increased expression of CCL5 mRNA]; SLCO2A1 gene mutant form promotes the reaction [Bleomycin results in increased expression of IL1B mRNA]PMID:32828905
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