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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3046
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk3
Name: mitogen activated protein kinase 3
Acc ID: CHEBI:49662
Term: indometacin
Definition: A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Chemical ID: MESH:D007213
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk3decreases phosphorylationISOMAPK3 (Homo sapiens)6480464CTDIndomethacin results in decreased phosphorylation of MAPK3 proteinPMID:24312908
Mapk3increases phosphorylationISOMAPK3 (Homo sapiens)6480464CTDIndomethacin results in increased phosphorylation of MAPK3 proteinPMID:12485869 PMID:17341418
Mapk3multiple interactionsISOMAPK3 (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Indomethacin results in increased phosphorylation of MAPK3 protein]; 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Indomethacin results in increased phosphorylation of MAPK3 protein]; Arsenic Trioxide inhibits the reaction [Indomethacin results in decreased phosphorylation of MAPK3 protein]; Indomethacin inhibits the reaction [Arsenic Trioxide results in decreased phosphorylation of MAPK3 protein]; Indomethacin inhibits the reaction [HMGB1 protein results in increased phosphorylation of MAPK3 protein]PMID:17341418 PMID:24312908 PMID:34755645
Mapk3multiple interactionsISOMapk3 (Mus musculus)6480464CTDIndomethacin inhibits the reaction [Carrageenan results in increased phosphorylation of MAPK3 protein]; Indomethacin results in decreased phosphorylation of and results in decreased activity of MAPK3 proteinPMID:10993886 PMID:26418808
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