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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3046
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk3
Name: mitogen activated protein kinase 3
Acc ID: CHEBI:4027
Term: cyclophosphamide
Definition: A phosphorodiamide that is 1,3,2-oxazaphosphinan-2-amine 2-oxide substituted by two 2-chloroethyl groups at the amino nitrogen atom.
Chemical ID: MESH:D003520
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk3increases expressionEXP 6480464CTDCyclophosphamide results in increased expression of MAPK3 protein modified formPMID:19638304
Mapk3multiple interactionsEXP 6480464CTDCyclophosphamide results in increased phosphorylation of and results in increased activity of MAPK3 protein; NGF protein affects the reaction [Cyclophosphamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]PMID:15733095 PMID:17110531 PMID:17409261 PMID:19996110
Mapk3increases phosphorylationISOMapk3 (Mus musculus)6480464CTDCyclophosphamide results in increased phosphorylation of MAPK3 proteinPMID:19696094
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