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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3046
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk3
Name: mitogen activated protein kinase 3
Acc ID: CHEBI:31823
Term: mercury dichloride
Definition: A mercury coordination entity made up of linear triatomic molecules in which a mercury atom is bonded to two chlorines. Water-soluble, it is highly toxic. Once used in a wide variety of applications, including preserving wood and anatomical specimens, embalming and disinfecting, as an intensifier in photography, as a mordant for rabbit and beaver furs, and freeing gold from lead, its use has markedly declined as less toxic alternatives have been developed.
Chemical ID: MESH:D008627
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk3increases phosphorylationEXP 6480464CTDMercuric Chloride results in increased phosphorylation of MAPK3 proteinPMID:23415682
Mapk3increases phosphorylationISOMAPK3 (Homo sapiens)6480464CTDMercuric Chloride results in increased phosphorylation of MAPK3 proteinPMID:20951154
Mapk3increases phosphorylationISOMapk3 (Mus musculus)6480464CTDMercuric Chloride analog results in increased phosphorylation of MAPK3 protein; Mercuric Chloride results in increased phosphorylation of MAPK3 proteinPMID:10861847 PMID:21373768 PMID:29981841
Mapk3multiple interactionsISOMAPK3 (Homo sapiens)6480464CTD[2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] which results in decreased susceptibility to Mercuric Chloride; Acetylcysteine inhibits the reaction [Mercuric Chloride inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK3 protein]]; Acetylcysteine inhibits the reaction [Mercuric Chloride results in increased phosphorylation of MAPK3 protein]; Mercuric Chloride inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK3 protein]PMID:19327394 PMID:20951154 PMID:22910795
Mapk3multiple interactionsISOMapk3 (Mus musculus)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Mercuric Chloride analog results in increased phosphorylation of MAPK3 protein]; Mercuric Chloride inhibits the reaction [CD22 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]PMID:17656488 PMID:29981841
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