Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3046
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk3
Name: mitogen activated protein kinase 3
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk3decreases expressionEXP 6480464CTDGenistein results in decreased expression of MAPK3 mRNAPMID:16443925
Mapk3decreases phosphorylationEXP 6480464CTDGenistein results in decreased phosphorylation of MAPK3 proteinPMID:15781664
Mapk3multiple interactionsEXP 6480464CTD[Genistein co-treated with Methoxychlor] results in decreased expression of MAPK3 mRNA; Genistein inhibits the reaction [Capsaicin results in increased phosphorylation of MAPK3 protein]; Genistein inhibits the reaction [Galactosamine results in increased phosphorylation of MAPK3 protein]; Genistein inhibits the reaction [lead acetate results in increased phosphorylation of MAPK3 protein]; Genistein inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK3 protein]PMID:15385614 PMID:16443925 PMID:20685402 PMID:25620059 PMID:26797587
Mapk3decreases activityISOMAPK3 (Homo sapiens)6480464CTDGenistein results in decreased activity of MAPK3 proteinPMID:20673057
Mapk3decreases expressionISOMapk3 (Mus musculus)6480464CTDGenistein results in decreased expression of MAPK3 mRNAPMID:11880592
Mapk3increases phosphorylationISOMAPK3 (Homo sapiens)6480464CTDGenistein results in increased phosphorylation of MAPK3 proteinPMID:16840783 PMID:17088408 PMID:19038232 PMID:19720055
Mapk3multiple interactionsISOMAPK3 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Genistein results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Genistein results in increased phosphorylation of MAPK3 protein]; [1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester co-treated with Genistein] inhibits the reaction [Thapsigargin promotes the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]]; [Tretinoin co-treated with Genistein] results in increased phosphorylation of MAPK3 protein; [U 0126 results in decreased phosphorylation of [MAPK1 protein co-treated with MAPK3 protein]] which results in decreased susceptibility to Genistein; AG 1879 inhibits the reaction [Genistein results in increased phosphorylation of MAPK3 protein]; Genistein inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of MAPK3 protein]; Genistein inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Genistein inhibits the reaction [Thapsigargin promotes the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]]; Genistein results in increased activity of and results in increased phosphorylation of MAPK3 protein; Genistein results in increased expression of and results in increased phosphorylation of MAPK3 protein; Genistein results in increased phosphorylation of and results in increased activity of MAPK3 protein; MAPK3 gene mutant form inhibits the reaction [Genistein results in increased expression of FOS protein]; U 0126 inhibits the reaction [Genistein results in increased activity of and results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Genistein results in increased phosphorylation of MAPK3 protein]PMID:15090535 PMID:16149052 PMID:16251475 PMID:16840783 PMID:19038232 PMID:19427779 PMID:33396024
Mapk3multiple interactionsISOMapk3 (Mus musculus)6480464CTDGenistein analog inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK3 protein]; Genistein inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK3 protein]PMID:25447760 PMID:30734460
Go Back to source page   Continue to Ontology report