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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3031
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Smad2
Name: SMAD family member 2
Acc ID: CHEBI:28939
Term: N-acetyl-L-cysteine
Definition: An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.
Chemical ID: MESH:D000111
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Smad2decreases phosphorylationISOSMAD2 (Homo sapiens)6480464CTDAcetylcysteine results in decreased phosphorylation of SMAD2 proteinPMID:32947957
Smad2multiple interactionsISOSMAD2 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [[Cadmium Chloride co-treated with sodium arsenite] results in increased expression of SMAD2 mRNA]; Acetylcysteine inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]; Acetylcysteine inhibits the reaction [Water Pollutants, Chemical results in increased expression of SMAD2 mRNA]PMID:29408318 PMID:30317545
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